appleseed currently requires itself to be installed under common prefix: %%APPHOME%%. To run CLI or GUI version, execute the following commands, respectively: %%APPHOME%%/bin/appleseed.cli %%APPHOME%%/bin/appleseed.studio Until https://github.com/appleseedhq/appleseed/issues/2520 is resolved, you might want to create $HOME/shaders -> %%APPHOME%%/shaders symlink to help it find OSL shaders.