To activate SquirrelMail, you must complete the following steps: 1) Set up a VirtualHost or an alias in httpd.conf that points to %%SQUIRRELDIR%% 2) Make sure the following is set in your php.ini: file_uploads = On 3) Configure your installation. SQUIRRELMAIL WILL NOT WORK UNTIL THIS HAS BEEN DONE. cd %%SQUIRRELDIR%% && ./configure 4) It is best practice to change the data/user preference directory (under General Options) to somewhere outside of %%SQUIRRELDIR%%.